Diuretic/Cool Dialysate Trial

Stopped early · Not applicable

Conditions studied: Chronic Kidney Insufficiency

In brief

The proposed pilot study challenges the current widespread paradigm of discontinuing loop diuretics when initiating chronic HD and/or maintaining the dialysate at a constant temperature of 37 °C for all patients.

Key facts

Study ID

NCT02593526

Run by

University of New Mexico

People needed

11

Starts

2017-01-01

Expected to finish

2022-05-27

Last updated by the study team

2024-01-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Primary speaking language is English.
• Patient is HD naïve (Patient may still enroll as long as no more than 12 weeks of in-center HD have been performed prior to randomization)
• HD takes place at one of the participating Dialysis Clinic Inc. (DCI) sites during the data collection period.
• Daily urine output is over 500ml.
• Patients must be willing and able to sign the consent form.

You may not qualify if…

• RRF <5 mL/min/1.73 m2 as determined by iohexol GFR measurement.
• Allergy or contraindication to iohexol and/or bumetanide.
• Has been undergoing dialysis for more than 12 weeks.
• Expectation that native kidneys will recover.
• History of poor adherence to treatment.
• Unable to verbally communicate in English.
• Requires more than 3 HD treatments per week due to medical co-morbidity (such as, but not limited to: severe volume overload requiring frequent HD e.g. in systemic oxalosis, or requiring total parenteral nutrition).
• Scheduled for living donor kidney transplant in the next 6 months.
• Intention to change to peritoneal dialysis, or home HD in the next 6 months.
• Plan to relocate to another center within the next 7-8 months.
• Expected geographic unavailability at a participating HD unit for >2 consecutive weeks or >4 weeks total during the next 6 months (excluding unavailability due to hospitalizations)
• Post kidney transplantation
• Currently in an acute or chronic care hospital
• Life expectancy <6 months or intention to withdraw dialysis therapy within 6 months.
• Current pregnancy
• Actively planning to become pregnant in the next 8 months
• Nursing mothers
• Current use of investigational drugs
• Participation in another non-observational clinical trial that contradicts or interferes with the therapies or measured outcomes in this trial
• Unable or unwilling to follow the study protocol for any reason (including mental incompetence)
• Unable or unwilling to provide informed consent or sign IRB-approved consent form.
• The following special populations will not be included in this study:
• Patients who are too infirm or lack the capacity to meaningfully participate in medical decisions and to sign the informed consent.
• Children and adolescents constitute <2% of the dialysis population, and our preliminary survey of the study sites found no children and adolescents were active patients. In any case, the renal and other physical factors of children and adolescents with ESRD are not directly comparable to those of adults.
• Prisoners.

Where it is running

• Dialysis Clinic Inc. - Indian School — Albuquerque, New Mexico, United States

Full record on ClinicalTrials.gov

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