Effect of Broccoli Sprout Extract on Keratinocyte Differentiation in Normal Skin

Completed · Phase 1 · Has a placebo group

Conditions studied: Epidermolysis Bullosa Simplex, Pachyonychia Congenita

In brief

Adult participants will apply a broccoli sprout extract-jojoba oil compound to one arm every night under occlusion for 1 week. Jojoba oil alone will be applied to the other arm. At the end of 1 week, a 6mm punch biopsy will be taken from both arms and analyzed via polymerase chain reaction (PCR) and immunohistochemistry for differences in various skin proteins.

Key facts

Study ID

NCT02592954

Run by

Johns Hopkins University

People needed

5

Starts

2015-09-01

Expected to finish

2016-12-01

Last updated by the study team

2017-12-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Able to attend 3 visits at the designated times.

You may not qualify if…

• Pregnant
• Known allergy to broccoli, lidocaine, or epinephrine

Where it is running

• Johns Hopkins Hospital — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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