High Sensitivity cTnT Rules Out Cardiac Insufficiency Trial (TACIT)

Completed

Conditions studied: Heart Failure

In brief

The purpose of this study is to better understand myocardial injury in AHF. Secondary analyses demonstrate the prognostic significance of troponin release. The absence of such release has been associated with less risk. Whether measurement of high sensitivity TnT may enable emergency physicians to better risk stratify acute heart failure patients remains to be determined. This study will help us to better understand the prognostic value of absent or low hsTnT values in the emergency department setting. In addition, we will also test the STRATIFY decision rule; a risk score.

Key facts

Study ID

NCT02592135

Run by

Indiana University

People needed

500

Starts

2015-12-21

Expected to finish

2018-05-31

Last updated by the study team

2018-06-04

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥21 years old
• Patient diagnosed with acute heart failure (AHF) by the treating physician.
• Patient has received IV loop diuretic or vasodilator therapy (by any route) for AHF
• Provide informed written consent
• SBP > 100mmHg

You may not qualify if…

• Life expectancy ≤6 months
• Shock of any kind or use or planned use of inotropes (dobutamine, dopamine, milrinone) or vasopressors. Any form of vasodilator is allowed.
• Fever > 101.5
• Presumed ACS as primary reason for presentation or ACS within 30 days. Patients with troponin release outside of ACS (Type 2 MI) may be included
• AF with RVR > 130bpm at any time requiring medical intervention
• History of transplant of any kind or VAD patient
• ESRD requiring dialysis
• Involved in any investigational trial (observational study where there is no intervention is allowed)
• Currently under treatment for cancer of any kind
• Alcohol or other substance abuse
• Any patient whom the investigator deems would be difficult to obtain follow-up

Where it is running

• Eskenazi Health — Indianapolis, Indiana, United States
• IU Health Methodist Hospital — Indianapolis, Indiana, United States
• Detroit Receiving Hospital — Detroit, Michigan, United States
• University of Cincinnati — Cincinnati, Ohio, United States
• Vanderbilt University — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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