Treatment of Hypertension In Adults With ThiaZIDES: Pragmatic Trial Pilot Study

Completed · Not applicable

Conditions studied: Hypertension

In brief

This proposed pilot study will test methods and feasibility for a large pragmatic clinical trial comparing two inexpensive, first-line drugs for treating high blood pressure to determine if one is superior in preventing serious cardiovascular events and death. It will develop and test novel approaches to conducting trials that will be faster, less expensive, and more realistic by being embedded in a typical practice setting and using advanced health information technology.

Key facts

Study ID

NCT02591628

Run by

HealthPartners Institute

People needed

2027

Starts

2015-08-01

Expected to finish

2017-07-01

Last updated by the study team

2017-10-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults 18 years and older
• Hypertension diagnosis (ICD-9 401.x)
• Current prescription for hydrochlorothiazide (HCTZ), 12.5-50 mg/day as a single-agent (not part of a fixed-dose combination drug)
• No history of intolerance to chlorthalidone (CTD)
• No known low levels of sodium (<135 mEg/L (milliequivalents per liter)) or potassium (<3.5 mEg/L)
• English speaking

You may not qualify if…

• Physician deems patient inappropriate for switching HCTZ to CTD
• Patient refuses the switch prior to intervention

Where it is running

• HealthPartners Institute for Education and Research — Bloomington, Minnesota, United States
• Kaiser Permanente Center for Health Research — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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