An Intervention to Reduce Delirium After Cardiac Surgery
Completed · Not applicable
Conditions studied: Delirium, Congenital Heart Disease, Coronary Artery Disease, Heart Valve Disease
In brief
Patients that have cardiac surgery may suffer from unrecognized cerebral ischemia or loss of blood flow to the brain temporarily during surgery. This temporary loss of blood flow to the brain may result in a condition called delirium. Delirium is a type temporary confusion. There are some strategies that can help reduce cerebral ischemia during cardiac surgery which can help lead to a reduction in the incidence of delirium. The investigator believes that a strategy called remote ischemic preconditioning will help to reduce the incidence of delirium incidence after cardiac surgery. Remote ischemic preconditioning is a brief exposure to ischemia. This brief exposure to ischemia occurs in an area of the body that is not undergoing a procedure. This brief exposure to ischemia is not long enough to cause any damage to the body and it has been demonstrated to help protect against more severe ischemic injury that may occur later during surgery. In this study the investigator will use remote ischemic preconditioning to see if it can reduce the incidence delirium after cardiac surgery.
Key facts
- Study ID
- NCT02587039
- Run by
- Johns Hopkins University
- People needed
- 53
- Starts
- 2014-06-01
- Expected to finish
- 2015-12-01
- Last updated by the study team
- 2016-08-11
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ≥65 years old
- Undergoing coronary artery bypass and/or valve surgery
You may not qualify if…
- Mini mental state exam < 23
- Delirium at baseline
- Inability to speak and understand English
- Severe hearing impairment, resulting in inability to converse
- Planned use of intraoperative ketamine
- Inability to place or tolerate upper extremity tourniquet
- Hemoglobinopathy (e.g. sickle cell disease)
Where it is running
- The Johns Hopkins Hospital — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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