Evaluation of Acute and Subacute Effects of Nicotine Free Electronic Cigarette(NCFE) Vapors

Stopped early · Not applicable

Conditions studied: Healthy Lifetime Non-smokers

In brief

This aim will examine the acute and subacute exposures to electronic cigarette (EC) vapor generated from e-liquids without nicotine (NFEC) on life-time non smokers subjects by measuring changes in nasal ion transport and TGF-β levels. Nasal ion transport will be assessed by nasal potential difference (NPD). Tumor growth factor (TGF)-β levels (mRNA and protein by ELISA) will be assessed on nasal cells and lavages.

Key facts

Study ID

NCT02585791

Run by

University of Miami

People needed

30

Starts

2017-02-22

Expected to finish

2019-12-11

Last updated by the study team

2020-01-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• INCLUSION CRITERIA:
• Subjects will be over 18 years of age.
• Healthy life-time non-smokers

You may not qualify if…

• Presence of airflow obstruction (COPD, asthma, bronchiectasis)
• Other concomitant inflammatory pulmonary disorders
• Subjects with known pulmonary malignancies within 5 years
• Subjects with prior thoracic surgery
• Subjects with respiratory infection that required use of oral corticosteroids and/or antibiotics within the prior 3 months
• Subjects with allergies to study medications
• Subjects incapable of providing informed consent.

Where it is running

• University of Miami School of Medicine — Miami, Florida, United States

Full record on ClinicalTrials.gov

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