Study to Evaluate Safety, Efficacy, Pharmacokinetics And Pharmacodynamics Of Avelumab In Combination With Either Crizotinib Or PF-06463922 In Patients With NSCLC. (Javelin Lung 101)
Stopped early · Phase 1/Phase 2
Conditions studied: Non-Small Cell Lung Cancer
In brief
The purpose of this study is to evaluate the safety and efficacy of avelumab when combined with either crizotinib or PF-06463922.
Key facts
- Study ID
- NCT02584634
- Run by
- Pfizer
- People needed
- 43
- Starts
- 2015-12-18
- Expected to finish
- 2022-07-13
- Last updated by the study team
- 2023-07-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- No prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or anti-CTLA-4 antibody.
- No Severe or Chronic medical conditions including gastrointestinal abnormalities or significant cardiac history
- No active infection requiring systemic therapy
- Prior organ transplantation including allogenic stem cell transplantation.
Where it is running
- Emory University Hospital Midtown — Atlanta, Georgia, United States
- Emory University Hospital — Atlanta, Georgia, United States
- The Emory Clinic — Atlanta, Georgia, United States
- Winship Cancer Institute of Emory University — Atlanta, Georgia, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Ophthalmic Consultants of Boston Inc (OCB) — Boston, Massachusetts, United States
- Tennessee Oncology, PLLC — Nashville, Tennessee, United States
- Chris O'Brien Lifehouse — Camperdown, New South Wales, Australia
- The Prince Charles Hospital — Chermside, Queensland, Australia
- Peter MacCallum Cancer Centre — Melbourne, Victoria, Australia
- Royal Melbourne Hospital — Parkville, Victoria, Australia
- Aichi cancer center central hospital — Nagoya, Aichi-ken, Japan
- National Hospital Organization Kyushu Cancer Center — Fukuoka, Japan
- The Cancer Institute Hospital of JFCR — Koto-ku, Tokyo, Japan
- National Cancer Center — Goyang-si, Gyeonggi-do, South Korea
- Asan Medical Center — Seoul, South Korea
- Samsung Medical Center — Seoul, South Korea
- Institut Catala d'Oncologia de Badalona — Badalona, Barcelona, Spain
- Hospital Quiron Barcelona — Barcelona, Spain
- Hospital Universitari de la Vall d'Hebron — Barcelona, Spain
Full record on ClinicalTrials.gov
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