Treatment of Brain Metastases From Breast Cancer With Eribulin Mesylate

Completed · Phase 2

Conditions studied: Metastatic Breast Cancer, Brain Metastases

In brief

Subjects are asked to take part in a clinical research study that tests Eribulin, a new drug. Eribulin is an investigational (experimental) anti-cancer agent that has not been approved by the Food and Drug Administration (FDA) for use in patients with brain metastases. Eribulin is FDA approved for use in patients with metastatic breast cancer but the effect it may or may not have on brain metastases has not been studied.

Key facts

Study ID

NCT02581839

Run by

Case Comprehensive Cancer Center

People needed

9

Starts

2015-11-17

Expected to finish

2020-07-02

Last updated by the study team

2020-07-30

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female with histologically confirmed breast cancer.
• Patients must have evidence of metastatic disease (non measurable disease is eligible).
• Radiologically confirmed metastatic brain lesion by MRI.
• Brain metastases from breast cancer with or without prior WBRT, STS of surgical resection. Progression must be documented in an at least one lesion untreated by SRS or in any site after surgery or WBRT.
• Patients must be neurologically stable and with stable dose steroids and anticonvulsants for at least 1 week prior to obtaining the baseline MRI of the brain, and/or at least 1 week prior to beginning study treatment.
• No presence of uncontrolled systemic disease or tumor related complication which, in opinion of the investigator, might restrict life expectancy to less than 3 months.
• Patients may not be on any cytotoxic chemotherapy or hormonal treatment for breast cancer during protocol treatment. Trastuzumab is allowed in HER2 positive patients).
• Able to comprehend and willing to sign an Informed Consent Form (ICF)
• Karnofsky performance status ≥ 60
• No brain radiation therapy > 4 weeks
• No chemotherapy for > 3 weeks before planned start of protocol treatment
• Adequate bone marrow, renal, and hepatic function, per local reference laboratory ranges as follows:
• Absolute neutrophil count (ANC) ≥ 1,500/mm3
• Platelet count ≥ 100,000/mm3
• Hemoglobin ≥ 9 g/dL
• Calculated creatinine clearance (CrCl) ≥ 30mL/min (Cockcroft-Gault method)
• Patients with normal, mild or moderate hepatic dysfunction are eligible.
• Calcium <10.1 mg/dL (corrected to serum albumin as follows: Corrected Calcium = (0.8 x (4 - patient albumin)) + serum Ca
• Females of child-bearing potential must have a negative pregnancy test at screening and agree to take appropriate precautions to avoid pregnancy (double barrier method of birth control or abstinence) from screening through 3 months after the last dose of treatment
• Able to undergo MRI evaluation with and without gadolinium contrast

You may not qualify if…

• Patients with the presence of an active infection, abscess or fistula
• Known leptomeningeal disease or CNS midline shifts.
• Any evidence of severe or uncontrolled systemic disease such as clinically significant cardiovascular, pulmonary, hepatic, renal or metabolic disease.
• Severe conduction abnormality including significant QTc prolongation >450ms.
• Patients with grade 3/4 peripheral neuropathy.
• Patients with pacemaker or an ICD devices.
• Previous treatment with eribulin mesylate.

Where it is running

• University Hospitals Cleveland Medical Center, Seidman Cancer Center, Case Comprehensive Cancer Center — Cleveland, Ohio, United States
• Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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