Acute Lymphoblastic Leukemia Therapies Informed by Genomic Analyses

Stopped early · Not applicable

Conditions studied: Leukemia, Acute Lymphoblastic

In brief

Previous work performed by University of New Mexico Comprehensive Cancer Center (UNMCCC) investigators has revealed previously unknown genomic mutations in children, adolescents, and young adults with high-risk B and T cell precursor acute lymphoblastic leukemia (ALL). Using genomic and next generation DNA sequencing technologies, these investigators revealed that 14% of children with high-risk ALL have "Philadelphia chromosome-like" ("Ph-like") ALL. Patients with this form of ALL were found to have a significantly increased risk of treatment failure and death. Further work revealed that there are more than 40 distinct gene rearrangements and fusions that can result in Ph-like ALL. Cell lines and human leukemic cells expressing some of these different gene fusions were sensitive to currently available drugs. This suggests that Ph-like ALL patients with these specific distinct gene fusions should be targeted in future clinical trials to be treated with appropriate therapy. Further work is also needed to identify other potentially targetable genetic alterations in ALL patients. Therefore, the goal of this study is to perform genomic screening of all newly diagnosed ALL patients seen at UNM and to use this information to enroll patients onto available National Clinical Trial Network (NCTN) clinical trials. If an appropriate NCTN trial is not available, best clinical management will be pursued.

Key facts

Study ID

NCT02580981

Run by

New Mexico Cancer Research Alliance

People needed

21

Starts

2016-07-28

Expected to finish

2022-10-20

Last updated by the study team

2024-01-11

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• New diagnosis of Acute Lymphoblastic Leukemia
• No previous therapy, excluding emergency radiation, steroids or intrathecal cytarabine
• Any age
• Ability to understand and the willingness to sign a written informed consent document.

You may not qualify if…

• Previous therapy, excluding emergency radiation, steroids or intrathecal cytarabine
• Not willing to obtain cancer care at the University of New Mexico

Where it is running

• University of New Mexico Comprehensive Cancer Center — Albuquerque, New Mexico, United States

Full record on ClinicalTrials.gov

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