Quantitative Imaging Biomarkers for Sarcoma
Completed · Not applicable
Conditions studied: Sarcoma
In brief
Unless a cancer quickly gets smaller with radiation or chemotherapy, the investigators cannot tell if the treatment is working or not. In this research program, two techniques using magnetic resonance imaging (MRI) scanning will be tested in people who have sarcomas, which are rare cancers starting in muscle, tendons, and bones. These particular MRI tests are called dynamic contrast enhanced MRI and diffusion weighted MRI. These MRI scans allow visualization of how sarcomas are different from the normal organs of the body. These MRI tests will tell us the location of sarcoma and its proximity to other structures, as well as correlation of imaging with pathological characteristics after surgery
Key facts
- Study ID
- NCT02579980
- Run by
- Columbia University
- People needed
- 32
- Starts
- 2015-10-01
- Expected to finish
- 2017-12-01
- Last updated by the study team
- 2019-03-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- New diagnosis of de novo sarcoma of all histologies (including soft tissue sarcoma, osteosarcoma, Ewing sarcoma, and chondrosarcoma) confirmed by biopsy
- Scheduled to be treated with surgical resection at the sarcoma or cancer center of participating sites
- Availability of the patient's medical information
- Provide written informed consent for the study
- Eighteen years of age or older
- Ability to remain motionless in MRI scanner for approximately 40 minutes
You may not qualify if…
- Patients with contra-indications for contrast enhanced MR exam, including:
- Cardiac pacemaker or pacemaker wiring in situ
- Cerebral clips or metal artificial cardiac valves
- Ossicle prosthesis
- Conditions that could produce a dangerous situation in the presence of a strong magnetic field: line metallic implants, shrapnel, inability to lie still, and conditions that can worsen inside confined spaces (severe claustrophobia, psychosis)
- Acute or chronic severe renal disease as determined by glomerular filtration rate (GFR) < 30 ml/min/1.73m2
- Pregnancy or breastfeeding
Where it is running
- Columbia University Medical Center — New York, New York, United States
- Huntsman Cancer Institute, University of Utah — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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