Reflux-Induced Oxidative Stress in Barrett's Esophagus: Response, Repair, and Epithelial-Mesenchymal-Transition

Completed · Not applicable

Conditions studied: Barrett's Esophagus, Gastroesophageal Reflux Disease

In brief

The purpose of this study is to elucidate mechanisms whereby oxidative stress induced by acute reflux esophagitis: 1) activates p38 to regulate proteins that control the G1/S cell cycle checkpoint, and 2) activates HIFs (hypoxia inducible factors) to cause autocrine VEGF (vascular endothelial growth factor) signaling that triggers the EMT (epithelial-mesenchymal-transition) program in Barrett's esophagus.

Key facts

Study ID

NCT02579460

Run by

Dallas VA Medical Center

People needed

15

Starts

2015-11-01

Expected to finish

2017-11-01

Last updated by the study team

2023-09-11

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• U.S. Veteran
• Barrett's Esophagus

You may not qualify if…

• Inability to provide informed consent
• Pregnancy or breastfeeding
• Esophageal varices
• Warfarin use
• Coagulopathy that precludes safe biopsy of the esophagus
• Comorbidity that precludes safe participation in the study

Where it is running

• Dallas VA Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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