Safety, Pharmacokinetics and Pharmacodynamics of BMS-936559 in Severe Sepsis

Stopped early · Phase 1 · Has a placebo group

Conditions studied: Severe Sepsis, Septic Shock

In brief

The purpose of this study is to determine whether BMS-936559 is safe and has the desired pharmacologic activity in patients who have severe sepsis.

Key facts

Study ID

NCT02576457

Run by

Bristol-Myers Squibb

People needed

35

Starts

2015-12-02

Expected to finish

2017-03-15

Last updated by the study team

2017-09-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Severe sepsis or septic shock for at least 24 hours
• Documented or suspected infection
• Sepsis-induced immunosuppression
• Men and women ≥ 18 years old

You may not qualify if…

• Autoimmune disease
• Organ transplant or bone marrow transplant
• Cancer treated in the past 6 months
• Hepatitis B virus (HBV) Infection
• Human Immunodeficiency Virus (HIV) infection and not on therapy prior to this episode of sepsis
• Hepatitis C virus (HCV) infection and still has virus (not cured)

Where it is running

• Uc Davis Medical Center — Sacramento, California, United States
• Local Institution — Denver, Colorado, United States
• University Of Florida — Gainesville, Florida, United States
• Emory University — Atlanta, Georgia, United States
• Osf Saint Francis Medical Center — Peoria, Illinois, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Baystate Medical Center — Springfield, Massachusetts, United States
• University of Michigan, Division of Acute Care Surgery — Ann Arbor, Michigan, United States
• Washington University School Of Medicine — St Louis, Missouri, United States
• The Ohio State University — Columbus, Ohio, United States
• St. Vincent'S Medical Center — Toledo, Ohio, United States
• UPMC — Pittsburgh, Pennsylvania, United States
• Local Institution — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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