Acute Mechanical Response to Anti-arrhythmic Drug Therapy

Withdrawn before enrolling · Not applicable

Conditions studied: Arrhythmias

In brief

The aim of this study is to determine if anti-arrhythmic drugs with a sodium channel-blocking mechanism exert a detrimental electromechanical effect on cardiac function in patients depending upon baseline intraventricular conduction and left ventricular function.

Key facts

Study ID

NCT02575534

Run by

Evan Adelstein, MD

People needed

0

Starts

2015-10-01

Expected to finish

2018-02-27

Last updated by the study team

2018-06-28

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Implanted cardiac device requiring generator change and a new device
• Able to give informed consent

You may not qualify if…

• Current membrane-active anti-arrhythmic
• Glomerular filtration rate (GRF)<30 milliliters (mL)/min
• MAP<60 mmHg
• Known intolerance to procainamide
• Pregnancy
• Age <18 or >85 years old
• Baseline QT interval >480 ms (500 ms if paced)

Where it is running

• Evan Adelstein — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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