Answer ALS: Individualized Initiative for ALS Discovery
Completed
Conditions studied: Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Flail Arm ALS, Progressive Muscular Atrophy, Monomelic Amyotrophy, Motor Neuron Disease, Asymptomatic ALS Gene Carriers, Healthy Controls
In brief
Creation of a large repository of induced pluripotent stem cells (iPSC), bio-fluid samples (blood and spinal fluid (optional)), and cell lines for ALS gene identification. This will be combined carefully with collected measures of the pattern of the symptoms people with ALS have and how these change over time. People with other motor neuron diseases and healthy controls will be included as comparisons
Key facts
- Study ID
- NCT02574390
- Run by
- Johns Hopkins University
- People needed
- 1049
- Starts
- 2015-12-01
- Expected to finish
- 2020-01-01
- Last updated by the study team
- 2020-01-13
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participants with familial or sporadic ALS diagnosed as possible, laboratory-supported probable, probable or definite according to the World Federation of Neurology (WFN) El Escorial criteria, Primary Lateral Sclerosis Flail Arm ALS, Progressive Muscular Atrophy, Monomelic Amyotrophy, Motor Neuron Disease, Asymptomatic ALS Gene Carriers
- Participants who are ages 18-100, inclusive.
You may not qualify if…
- Participants with Spinal-Bulbar Muscular Atrophy
- Known diagnosis of HIV/AIDS, Hepatitis B, or Hepatitis C.
Where it is running
- Cedars-Sinai Medical Center — Los Angeles, California, United States
- Emory University — Atlanta, Georgia, United States
- Northwestern University Feinberg School of Medicine — Chicago, Illinois, United States
- Johns Hopkins University — Baltimore, Maryland, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- Ohio State University Wexner Medical Center — Columbus, Ohio, United States
- Texas Neurology — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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