A Study of Nivolumab in Advanced Non-Small Cell Lung Cancer (NSCLC)

Completed · Phase 1/Phase 2

Conditions studied: Non-Small Cell Lung Cancer

In brief

The purpose of this study is to determine whether nivolumab monotherapy or in combination with Standard of care (SOC) therapies will provide clinical benefit (i.e., PFS, OS, and DOR) without unacceptable toxicity in advanced Non-Small Cell Lung Cancer patients.

Key facts

Study ID

NCT02574078

Run by

Bristol-Myers Squibb

People needed

341

Starts

2015-11-23

Expected to finish

2020-04-15

Last updated by the study team

2021-05-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed locally advanced or stage IV NSCLC
• Eastern Cooperative Oncology Group (ECOG) Performance status (PS) 0-2
• Tumor tissue sections must be available for biomarker evaluation

You may not qualify if…

• Untreated or active/progressing Central Nervous system (CNS) metastases
• Active, known or suspected autoimmune disease
• Known history of testing positive for HIV or AIDS
• Active or chronic infection of hepatitis B virus or hepatitis C

Where it is running

• Southern Cancer Center Pc — Mobile, Alabama, United States
• Arizona Oncology Assoc, Pc-Hal — Glendale, Arizona, United States
• Northern Arizona Hematology & Oncology Associates — Sedona, Arizona, United States
• Arizona Oncol Assoc Dba (Hem Onc Physicians&Extenders) Hope — Tucson, Arizona, United States
• Arizona Clinical Research Center, Inc. — Tucson, Arizona, United States
• Comprehensive Blood And Cancer Center — Bakersfield, California, United States
• St. Joseph Heritage Medical Group — Fullerton, California, United States
• Scripps Cancer Center — La Jolla, California, United States
• UCLA Hematology/Oncology Clinic — Los Angeles, California, United States
• Coastal Integrative Cancer Care — San Luis Obispo, California, United States
• Central Coast Med Oncology — Santa Maria, California, United States
• Local Institution — Solvang, California, United States
• St. Mary's Hospital Regional Cancer Center — Grand Junction, Colorado, United States
• Rocky Mountain Cancer Centers — Lakewood, Colorado, United States
• Eastern Ct Hem Onc Assoc — Norwich, Connecticut, United States
• Stamford Hospital — Stamford, Connecticut, United States
• Va Ct Healthcare System — West Haven, Connecticut, United States
• Florida Cancer Specialists S. — Fort Myers, Florida, United States
• University of Florida at Shands — Gainesville, Florida, United States
• Memorial Cancer Institute — Hollywood, Florida, United States
• Baptist Health Medical Group Oncology — Miami, Florida, United States
• Ocala Oncology Center — Ocala, Florida, United States
• Hematology Oncology Associates Of The Treasure Coast — Port Saint Lucie, Florida, United States
• Florida Cancer Specialists — St. Petersburg, Florida, United States
• Alabama Oncology — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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