Patient-derived Xenograft Models of Tumor From Patients With Head and Neck Cancer

Recruiting now

Conditions studied: Squamous Cell Carcinoma of the Head and Neck

In brief

The investigators want to have a collection of fresh primary or recurrent tumor tissue for establishment of patients-derived xenografts in order to: generate a biobank of in vivo patient xenografts representing the different subgroups of tumors for head and neck cancer * perform genetic and transcriptional profiling of the primary, metastatic tumors and xenograft tumors * evaluate the efficacy of new targeted agents, whether or not in combination with standard treatment options * evaluate biomarkers of drug sensitivity * study primary and secondary (acquired) resistance in these models

Key facts

Study ID

NCT02572778

Run by

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

People needed

40

Starts

2015-09-01

Expected to finish

2025-12-01

Last updated by the study team

2024-12-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• In the first phase, all patients with primary or recurrent/ metastatic disease of head and neck cancer can be included pre-operatively or before a tumor biopsy after obtaining informed consent
• Data on stage, grade, histology, adjuvant treatment, responses, relapse should be available
• Follow-up data should be available
• Patients with recurrent disease are allowed
• Written informed consent

Where it is running

• Cliniques universitaires Saint-Luc — Brussels, Belgium (enrolling)

Full record on ClinicalTrials.gov

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