Dorzolamide-timolol Drops With Injections to Treat AMD, RVO or DME.

Completed · Phase 2

Conditions studied: Wet Macular Degeneration, Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion

In brief

This study seeks to evaluate the effect of topical aqueous suppression on the anatomic and functional response to intravitreal anti-vascular endothelial growth factor (VEGF) injections in non-responders with wet age-related macular degeneration.

Key facts

Study ID

NCT02571972

Run by

Wills Eye

People needed

14

Starts

2015-02-01

Expected to finish

2015-12-20

Last updated by the study team

2019-12-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient of Wills Eye Hospital Retina Service and/or Mid Atlantic Retina.
• Volunteer patients age 18 years and older.
• Healthy enough to participate in the study.
• Willing and able to consent to participation in the study.
• Diagnosis of wet age-related macular degeneration
• Prior treatment with at least 4 injections of anti-VEGF agents in the past 6 months and persistent intraretinal and/or subretinal fluid on SD-OCT at each visit during this period
• Injection of the same anti-VEGF agent for at least two visits prior to study enrollment
• Fixed interval between at least two visits prior to study enrollment

You may not qualify if…

• History of uveitis
• Any ophthalmic surgery within previous 6 months, including cataract extraction.
• Any history of vitrectomy
• History of any glaucoma drop usage or prior glaucoma surgery
• Systemic diuretic or corticosteroid usage
• Any contraindication (bradycardia, decompensated heart failure, or reactive
• airway disease) for topical use of a beta-blocker
• Any history of sulfonamide allergy

Where it is running

• Wills Eye Hospital / Mid Atlantic Retina — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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