Oxytocin MEG Study

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Schizophrenia, Oxytocin, Magnetoencephalography (MEG), Social Cognition

In brief

The specific aim of this proposal is to investigate the neurophysiological mechanisms of oxytocin's (OT) prosocial effects in patients with schizophrenia and healthy subjects using magnetoencephalography. Hypothesis A: When OT is administered to patients with schizophrenia, fear-related amygdala hyperreactivity and fusiform gyrus (FG) and anterior cingulate cortex (ACC) hypoactivity will be normalized. Hypothesis B: When OT is administered to patients with schizophrenia, the decreased functional connectivity (FC) between the amygdala, FG, and ACC will be normalized. By elucidating the neurophysiological mechanisms of OT administration on emotional face processing, investigators will bee able to: 1. understand the pathophysiology of the functionally debilitating social cognitive deficits of schizophrenia, 2. test the efficacy of OT in normalizing the neural abnormalities underlying these social deficits, and 3. develop and optimize novel treatments for these currently untreatable deficits.

Key facts

Study ID: NCT02568709
Run by: University of California, San Francisco
People needed: 40
Starts: 2012-02-01
Expected to finish: 2016-12-01
Last updated by the study team: 2019-05-21

Who can join

Age: 18 and older, up to 40. Sex: male. Healthy volunteers: accepted.

You may not qualify if…

Female
Active substance abuse or dependence as determined by a Urine Toxicology Drug Screening
DSM-IV diagnosis of any disorder other than schizophrenia
Medical conditions (atrophic rhinitis, recurrent nose bleeds and cranial surgical procedures (hypophysectomy), congestion or sinus problems that could interfere with the study as per the opinion of the investigator
Hearing deficits
A pacemaker, extensive dental work, or any magnetic metal implants
Any history of severe brain trauma

Where it is running

University of California, San Francisco — San Francisco, California, United States

Full record on ClinicalTrials.gov

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