Adult Study Oxytocin - fMRI

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Schizophrenia, Oxytocin, Social Cognition, Functional Magnetic Resonance Imaging (fMRI)

In brief

In this study, investigators will examine the behavioral effects and neurophysiological mechanisms of the pro-social neuropeptide oxytocin in patients with recent-onset schizophrenia. Such research is a necessary first step towards identifying whether intranasal oxytocin administration can serve as an adjunct treatment for social impairments in schizophrenia. Aim 1: To examine the effects of exogenous oxytocin on patterns of neural activation as measured by fMRI during a well-characterized affect-labeling task in patients with recent-onset schizophrenia and healthy comparison subjects. Hypothesis A: Patients will exhibit amygdalar hyperactivity and PNS hypo-activity when passively viewing faces, which will be normalized by administration of oxytocin. Hypothesis B: Patients will exhibit hypo-activity of the vPFC when affectively labeling faces and this hypo-activity will be normalized by oxytocin administration.

Key facts

Study ID
NCT02566356
Run by
University of California, San Francisco
People needed
59
Starts
2012-09-01
Expected to finish
2017-09-01
Last updated by the study team
2019-05-21

Who can join

Age: 18 and older, up to 50. Sex: male. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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