Determination of Upper Airway Collapsibility During Routine CPAP Titration
Stopped early · Not applicable
Conditions studied: Obstructive Sleep Apnea
In brief
The investigators hypothesis is that upper airway collapsibility (Pcrit) in patients with obstructive sleep apnea (OSA) can be measured using equipment found in the clinical sleep laboratory and these Pcrit measurements obtained using clinical sleep laboratory equipment is comparable to those obtained using research equipment. OSA is a common disease characterized by repetitive collapse of the upper airway during sleep, leading to hypoxemia and arousals, and which has important neurocognitive and cardiovascular consequences. The single most important factor in the development of OSA is upper airway collapsibility: those with a more collapsible upper airway tend to have OSA while those with a stiffer upper airway do not. The gold standard treatment for OSA is continuous positive airway pressure (CPAP), which acts by stenting open the collapsible airway. Upper airway collapsibility can be measured during sleep by changing the CPAP level and assessing the change in inspiratory flow through the upper airway. Although technically feasible, these measurements are typically only undertaken in research laboratories with specialized equipment. The purpose of this study is to measure upper airway collapsibility using clinically available (i.e. equipment found in a clinical sleep laboratory) equipment only. If successful, upper airway collapsibility could be routinely measured in clinical practice, which could help inform treatment decisions and help individualize therapy for OSA.
Key facts
- Study ID
- NCT02566278
- Run by
- University of California, San Diego
- People needed
- 20
- Starts
- 2015-10-20
- Expected to finish
- 2016-07-25
- Last updated by the study team
- 2019-07-10
Who can join
Age: 18 and older, up to 79. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of OSA and stable on CPAP treatment > 3 months
You may not qualify if…
- Pregnancy
- Currently smoking
- Any respiratory disorder other than OSA or well controlled asthma
- Medications known to affect respiratory function (e.g. opioids, benzodiazepines, etc)
Where it is running
- University of California, San Diego — San Diego, California, United States
Full record on ClinicalTrials.gov
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