PF-06669571 In Subjects With Idiopathic Parkinson's Disease

Completed · Phase 1 · Has a placebo group

Conditions studied: Idiopathic Parkinson's Disease

In brief

This study is designed to assess safety, tolerability and pharmacokinetic data for multiple doses of PF-06669571 in subjects with idiopathic Parkinson's disease. In addition, this study will assess whether PF-06669571 is able to demonstrate superior efficacy compared with placebo in the treatment of the motor symptoms of idiopathic Parkinson's disease.

Key facts

Study ID

NCT02565628

Run by

Pfizer

People needed

20

Starts

2015-11-16

Expected to finish

2016-05-13

Last updated by the study team

2023-07-24

Who can join

Age: 45 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects must have a clinical diagnosis of idiopathic Parkinson's disease and presence of at least 2 out of 3 cardinal characteristics (tremor, rigidity and/or bradykinesia).
• Must be Hoehn \& Yahr Stage II-III inclusive and experiencing motor fluctuations in the form of end-of-dose wearing off during the morning hours or early morning akinesia.
• Subjects should be able to recognize their "wearing off" symptoms and verify that they usually improve after their next dose of Parkinson's disease medication. Subjects should be able to recognize drug-induced dyskinesias and verify whether or not they are troublesome.

You may not qualify if…

• History or clinical features consistent with an atypical parkinsonian syndrome, (for example: ataxia, dystonia, clinically significant orthostatic hypotension.

Where it is running

• Pfizer New Haven Clinical Research Unit — New Haven, Connecticut, United States
• MD Clinical — Hallandale, Florida, United States
• QPS-MRA, LLC (Broward Research Group) — Hollywood, Florida, United States
• Qps-Mra Llc — South Miami, Florida, United States
• QPS-MRA, LLC (Miami research Associates) — South Miami, Florida, United States
• QPS-MRA, LLC (MRA Clinical Research) — South Miami, Florida, United States
• Atlanta Center for Medical Research — Atlanta, Georgia, United States
• CRI Worldwide, LLC — Marlton, New Jersey, United States
• CTI Clinical Research Center — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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