A Study of Ramucirumab (LY3009806) in Children With Refractory Solid Tumors

Completed · Phase 1

Conditions studied: Pediatric Solid Tumor, Refractory Tumor, Recurrent Tumor, CNS Malignancies

In brief

The main purpose of this study is to evaluate the safety of the study drug known as ramucirumab in children with recurrent or refractory solid tumors including central nervous system (CNS) tumors.

Key facts

Study ID

NCT02564198

Run by

Eli Lilly and Company

People needed

29

Starts

2015-12-11

Expected to finish

2019-07-16

Last updated by the study team

2021-08-17

Who can join

Age: 1 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Part A: participants with recurrent or refractory non-CNS solid tumors
• Part B: participants with recurrent or refractory CNS tumors
• Measurable or evaluable disease
• No other therapeutic options
• Performance Status: Karnofsky ≥50% for participants >16 years and Lansky ≥50 for participants ≤16 years

You may not qualify if…

• Active or recent history of serious bleeding events
• Active or recent history of gastrointestinal perforations, ulcers, fistulas or abscesses
• Active or recent history of hypertensive crisis or hypertensive encephalopathy
• Active non-healing wound or bone fracture
• History of solid organ transplant

Where it is running

• Childrens Hospital of Alabama — Birmingham, Alabama, United States
• Children's Oncology Group — Monrovia, California, United States
• Childrens Hospital of Orange County — Orange, California, United States
• University of California, San Francisco — San Francisco, California, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• Children's Healthcare of Atlanta at Scottish Rite — Atlanta, Georgia, United States
• Ann & Robert H Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
• Riley Hospital for Children — Indianapolis, Indiana, United States
• Mark O Harfield-Warren Grant Magnuson Clinical Center — Bethesda, Maryland, United States
• University of Michigan Health Systems — Ann Arbor, Michigan, United States
• University of Minnesota Hospital — Minneapolis, Minnesota, United States
• Washington University Medical School — St Louis, Missouri, United States
• Columbia University Medical Center — New York, New York, United States
• Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Oregon Health and Science University — Portland, Oregon, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• Childrens Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States
• St Jude Childrens Research Hospital — Memphis, Tennessee, United States
• Texas Childrens Hospital — Houston, Texas, United States
• Seattle Children's Hospital Research Foundation — Seattle, Washington, United States
• Medical College of Wisconsin — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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