ARCH II Study (Alcohol Research Center on HIV Study II)
Completed · Not applicable
Conditions studied: Alcohol Consumption, HIV, Motivation
In brief
This study is being done to learn about the interaction of alcohol consumption and HIV on brain function. The proposed study will have two broad objectives. The first is to incorporate functional neuroimaging (FMRI) approaches, along with additional Magnetic Resonance Spectroscopy (MRS) methods that will enable a delineation in both functional and cerebral metabolic disturbances affecting specific functional brain systems that are associated with the interaction of ethanol (ETOH) consumption on Human Immunodeficiency Virus (HIV)-associated brain dysfunction. Recent data indicate that HIV infected patients with heavy ETOH consumption have FMRI abnormalities and exhibit alterations on other neuroimaging measures compared to moderate drinkers and people who do not drink at all. The second objective is to examine the extent to which reductions in ETOH consumption among heavy drinkers with HIV infection result from a motivational intervention. The findings from this study will provide important information on how heavy ETOH and HIV interact to affect the brain functional responsiveness, and the extent of improvement that might be gained by reducing heavy ETOH use.
Key facts
- Study ID
- NCT02563574
- Run by
- University of Florida
- People needed
- 14
- Starts
- 2016-12-01
- Expected to finish
- 2021-12-16
- Last updated by the study team
- 2022-04-04
Who can join
Age: 25 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- HIV-infected;
- English speaking;
- Physically mobile;
- Willingness to participate in the Motivational Interviewing (MI) to reduce ETOH consumption.
You may not qualify if…
- Neurological disorders;
- Evidence of dementia;
- Past opportunistic brain infection;
- Major psychiatric illness;
- Current major psychiatric disturbance;
- Unstable medical conditions (cancer);
- MRI contraindications (e.g., pregnancy, claustrophobia, metal implants);
- Physical impairment precluding motor response or lying still.
Where it is running
- University of Florida — Gainesville, Florida, United States
- Florida International University — Miami, Florida, United States
Full record on ClinicalTrials.gov
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