Comparison of Two Methods of Transfusion for Stroke Prevention in Sickle Cell

Completed

Conditions studied: Anemia, Sickle Cell, Sickling Disorder Due to Hemoglobin S

In brief

Chronic blood transfusions are essential supportive care for sickle cell patients at high risk for morbidity and mortality due to stroke. These patients, however, are at risk for iron overload. In the investigator's comprehensive sickle cell center, the investigators support chronic transfusion with rapid manual partial exchange transfusions (RMPET) using a single access central line port. The investigators do not have a comprehensive adult sickle cell program but upon transition of patients the patients would be provided simple transfusion (ST) in an adult ambulatory infusion setting due to nursing acuity needed for RMPET. The investigators plan to study the institution's participants currently on chronic transfusion support and compare different transfusion modalities to better understand the effects from switching from RMPET to ST. To date, there are no such comparisons within and between sickle cell patients in the literature.

Key facts

Study ID

NCT02561312

Run by

Chattanooga-Hamilton County Hospital Authority

People needed

9

Starts

2015-09-01

Expected to finish

2017-09-30

Last updated by the study team

2018-07-27

Who can join

Age: 3 and older, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants between 3 and 25 years of age
• Diagnosis of Hemoglobin SS or SBeta thalassemia
• On chronic exchange for stroke prevention
• Performance status: Lansky play score of 100%, and if over 16 years of age, Karnofsky=100%

You may not qualify if…

• Participant has experienced more than one stroke and has a modified Rankin Scale of >3.
• Diagnosis of Hemoglobin SC disease
• Participants on chronic transfusion for priapism.

Where it is running

• Chidlren's Hospital at Erlanger — Chattanooga, Tennessee, United States

Full record on ClinicalTrials.gov

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