Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV
Recruiting now · Phase 2 · Has a placebo group
Conditions studied: Stress Disorders, Post-Traumatic
In brief
The purpose of this study is to find out why patients with post-traumatic stress disorder (PTSD) have an increased risk for heart disease and high blood pressure later in life. A second purpose is to find out what causes PTSD patients to have high adrenaline levels during stress. This study will also test if a medicine called losartan improves high adrenaline levels in patients with PTSD and if a certain gene that has to do with high blood pressure might be associated with high adrenaline levels.
Key facts
- Study ID
- NCT02560805
- Run by
- Emory University
- People needed
- 134
- Starts
- 2015-10-01
- Expected to finish
- 2027-03-30
- Last updated by the study team
- 2026-05-18
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- veterans ages 18-65 years old with PTSD and without PTSD (controls) matched for age, gender, and race.
You may not qualify if…
- pregnancy
- hypertension
- diabetes
- heart or vascular disease
- illicit drug use
- excessive alcohol use (>2 drinks per day)
- hyperlipidemia
- autonomic dysfunction
- current treatment with clonidine, beta blockers, angiotensin-converting-enzyme (ACE) inhibitors, or angiotensin II receptor blockers (ARBs)
- treatment with monoamine oxidase (MAO) inhibitors within the last 14 days
- any serious systemic disease
- chronic kidney disease defined as estimated glomerular filtration rate (GFR) < 60 cc/min
- hyperkalemia (serum potassium > 5 meq/dL)
- systolic blood pressure < 100 mm Hg
- diastolic blood pressure < 60 mm Hg
- heart rate < 50 beats/min
- known hypersensitivity to ARBs or beta blockers
Where it is running
- Atlanta VA Medical Center — Decatur, Georgia, United States (enrolling)
Full record on ClinicalTrials.gov
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