Locomotor Adaptation Training to Prevent Mobility Disability

Completed

Conditions studied: Age-related Mobility Decline

In brief

This is an exploratory study designed to investigate the effects of aerobic dual belt treadmill walking versus traditional treadmill exercise on gait performance and functional capacity in older adults at risk for mobility disability. Identifying the relationship between aerobic treadmill exercise (dual belt or traditional) and the recovery of walking abilities will serve to optimize current rehabilitation approaches.

Key facts

Study ID

NCT02554916

Run by

University of Florida

People needed

58

Starts

2010-07-01

Expected to finish

2019-07-17

Last updated by the study team

2019-07-22

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 65 and older
• Gait Speed of ≤ 1m/s
• Summary score 7-10 on the Short Physical Performance Battery, indicating mild to moderate impairment
• Sedentary as defined by reporting <20 min/wk of performing regular physical activity in the past month and <125 min/wk of moderate physical activity on the CHAMPS-18 questionnaire
• Willingness to be randomized to any of the treatment groups

You may not qualify if…

• Failure to provide informed consent
• Planned surgery in next year
• Hospitalization within the past 6 months
• Smoker > 1 pack per day
• Significant cognitive impairment, defined as a known diagnosis of dementia or a Modified Mini-Mental State score <24
• Significant cognitive executive impairment, defined as a Montreal Cognitive Assessment (MoCA) score of<25
• Progressive, degenerative neurologic disease, e.g., Parkinson's Disease, multiple sclerosis, Amyotrophic lateral sclerosis (ALS)
• Severe rheumatologic or orthopedic diseases, e.g., awaiting joint replacement, active inflammatory disease
• Terminal illness with life expectancy less than 12 mos, as determined by a physician
• Severe pulmonary disease, requiring either steroid pills or injections or the use of supplemental oxygen
• Severe cardiac disease, including New York Heart Association Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina;
• Other significant co-morbid disease that would impair ability to participate in the exercise-based intervention, e.g. renal failure on hemodialysis, severe psychiatric disorder (e.g. bipolar, schizophrenia), excessive alcohol use (>14 drinks per wk); persons with depression will not be excluded
• Develops chest pain or severe shortness of breath during exercise test
• Unable to communicate because of severe hearing loss or speech disorder or language barrier
• Lives outside of the study site or is planning to move out of the area in next year or leave the area for >1 month during the next year
• Severe diabetes, requiring use of insulin

Where it is running

• University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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