Effect of Beetroot Juice on Coronary Blood Flow and Walking Performance in PAD
Status unconfirmed · Phase 2 · Has a placebo group
Conditions studied: Peripheral Arterial Disease
In brief
In this study the investigators will test the hypothesis that short-term consumption of inorganic nitrate (supplied in concentrated beetroot juice) enhances coronary blood flow responses, large artery hemodynamics, and leg oxygenation/exercise tolerance in patients with peripheral arterial disease (PAD). Understanding and improving blood flow regulation in the heart and skeletal muscles of patients with PAD is important because exercise triggers symptoms of leg pain and substantially raises blood pressure and myocardial demand in these patients.
Key facts
- Study ID
- NCT02553733
- Run by
- David N. Proctor, PhD
- People needed
- 12
- Starts
- 2015-12-01
- Expected to finish
- 2024-12-01
- Last updated by the study team
- 2023-04-06
Who can join
Age: 21 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with peripheral arterial disease (PAD)
- Capable of giving informed consent
- Men and women age 21- 85 years
- Diagnosed with PAD (i.e., ankle-brachial index below 0.9)
- Fontaine stage II or less - no pain while resting
- Satisfactory history and physical exam
You may not qualify if…
- Children
- Pregnant or nursing women
- Patients taking nitroglycerine or nitrate preparations
- Patients taking phosphodiesterase inhibitors such as sildenafil or tadalafil
- Patients taking proton pump inhibitors
- Ejection fraction < 40%
- Uncontrolled hypertension
- Uncontrolled diabetes
- Myocardial infarction within past 6 months or unstable angina
- Severe lung disease (i.e., on supplemental oxygen or frequently use rescue inhalers)
- Abnormality in hemoglobin or hematocrit or methemoglobin
- Impaired renal function
- Impaired liver function
- History or diagnosis of Barrett's esophagus
- Known allergy to beetroot juice or lemon juice
- Inability to walk on a treadmill at a moderate pace (2.0 miles/hour)
Where it is running
- Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States
Full record on ClinicalTrials.gov
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