Effects of Stimulation Patterns of Deep Brain Stimulation

Enrolling by invitation · Not applicable

Conditions studied: Parkinson Disease, Essential Tremor, Multiple Sclerosis, Dystonia

In brief

The purpose of this study is to measure the effects of non-regular temporal patterns of deep brain stimulation (DBS) on motor symptoms and neural activity in persons with Parkinson's disease (PD), essential tremor (ET), dystonia or multiple sclerosis (MS). These data will guide the design of novel stimulation patterns that may lead to more effective and reliable treatment with DBS. These data will also enable evaluation of current hypotheses on the mechanisms of action of DBS. Improving our understanding of the mechanisms of action of DBS may lead to full development of DBS as a treatment for Parkinson's disease and may lead to future applications of DBS.

Key facts

Study ID

NCT02553525

Run by

Duke University

People needed

180

Starts

2016-06-02

Expected to finish

2027-03-01

Last updated by the study team

2026-04-09

Who can join

Age: 21 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Parkinson's Disease (PD), Essential Tremor (ET) dystonia or Multiple Sclerosis (MS)
• Scheduled to undergo Deep Brain Stimulation (DBS) electrode implant, IPG implant or implanted pulse generator (IPG) replacement surgery
• Neurologically stable
• Able to understand the study and consent form

You may not qualify if…

• Inability to execute the motor tasks during the study
• Inability to tolerate withholding anti-parkinsonian and/or anti-tremor medications
• Clinically ineffective DBS

Where it is running

• University of Florida — Gainesville, Florida, United States
• Emory University — Atlanta, Georgia, United States
• Duke University — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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