AKI in Thoracic and Abdominal Surgery

Stopped early

Conditions studied: Acute Kidney Injury

In brief

The study will investigate the role of NSAIDs in the development of AKI in patients undergoing high-risk abdominal or thoracic surgery. The investigators hypothesize that the use of new urinary biomarkers will allow earlier detection of AKI than the current gold standard, i.e. changes in serum creatinine and/or urine output.

Key facts

Study ID

NCT02553174

Run by

Milton S. Hershey Medical Center

People needed

50

Starts

2016-06-01

Expected to finish

2018-03-23

Last updated by the study team

2018-04-02

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age ≥ 21 (per manufacturer's instructions on the Nephrocheck kit)
• history of hypertension, whether medically treated or untreated
• scheduled for Anesthesia preoperative clinic visit
• scheduled to undergo prolonged intra-abdominal or intra-thoracic surgeries (defined as scheduled intraoperative time ≥ 4h). Intra-abdominal surgeries will include colorectal surgery, massive ventral hernia repairs, hepatobiliary surgery and gynecologic-oncology surgery. Intra-thoracic surgeries will include video-assisted thoracoscopic surgery (VATS)-assisted segmentectomy and lobectomies, as well as mediastinal mass excisions.
• will be anticipated to be admitted to the ICU for a minimum of 2-3 days post-operatively

You may not qualify if…

• history of chronic kidney as defined by estimated glomerular filtration rate (GFR) <90
• patient taking NSAIDs on a daily basis
• patients with a reported allergy or intolerance to NSAIDs

Where it is running

• Penn State Milton S Hershey Medical Center — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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