Incretin Action in Physiology and Diabetes
Completed · Phase 1
Conditions studied: Insulin Secretion
In brief
This project is designed to advance understanding of the incretin effect in health and disease. This system of gut-islet linkage is essential for normal glucose tolerance, impaired in T2DM, and amenable to therapeutic intervention. However, there are important gaps in understanding incretin function that limit application of this system; this project will address several of these. A secondary, but critical aspect of this research is focus on inter-individual variation in the physiology of the incretin system. This is a novel direction for research in this field and is critical to advancing the concept of individualized medical care in diabetes by establishing whether there is a physiologic basis for predicting the existence of responders and non-responders to incretin therapies. Currently, we have described only Aim 1 from this grant in this protocol registration. While Aim 2 and 3 are described in the grant, Aim 1 will be conducted first and the results from this Aim and / or the publication of other results in the field may affect the approach to Aims 2 and 3.
Key facts
- Study ID
- NCT02550548
- Run by
- David D'Alessio, M.D.
- People needed
- 39
- Starts
- 2016-04-21
- Expected to finish
- 2021-04-16
- Last updated by the study team
- 2023-11-18
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- healthy adult volunteers
- fasting plasma glucose value ≤ 95 mg/dL, measured at screening visit
- HbA1c ≤ 5.9%, measured at screening visit
You may not qualify if…
- history of diabetes diagnosis, including gestational diabetes
- presence of Type II diabetes mellitus among any first degree family members
- rheumatoid arthritis
- inflammatory bowel disease
- unstable angina or uncompensated heart failure
- pulmonary disorders including COPD and asthma
- malabsorptive GI disease, such as celiac disease, or gastric bypass
- significant hepatic disease
- renal insufficiency (eGFR < 60 mL/kg/min)
- anemia (hematocrit < 34%) as measured at screening visit
- pregnancy
- uncontrolled hypertension
- consumption of daily medications that alter glucose metabolism or GI function (glucocorticoids, psychotropics, narcotics, metoclopramide)
Where it is running
- Duke Center for Living — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
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