Long-term Effect of Low Frequency Stimulation on Aspiration and Freezing of Gait in PD With STN DBS

Completed · Not applicable · Has a placebo group

Conditions studied: Parkinson's Disease

In brief

Our recent study (Xie et al, Neurology 2015; 84: 415-420) found that bilateral STN DBS of 60Hz, compared to the traditional 130Hz, decreased the aspiration frequency and swallowing difficulty, freezing of gait (FOG), and other axial symptoms and parkinsonism in Parkinson patients with FOG refractory to 130Hz and medications. The benefit of 60Hz stimulation persisted during the 6-week study period, but with worsening tremor in one patient. However, it remains unknown whether the benefit of 60Hz would persist on prolonged stimulation period, and whether there is carry-over effect across different conditions. Hence, the investigators would like to test the hypothesis that the 60Hz stimulation, compared to 130Hz might have persistent benefit over an extended period in reducing the swallowing dysfunction, FOG, and other axial symptoms in these PD patients even after correcting the potential carry-over effect.

Key facts

Study ID

NCT02549859

Run by

University of Chicago

People needed

11

Starts

2015-08-01

Expected to finish

2017-05-01

Last updated by the study team

2020-10-29

Who can join

Age: 45 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• PD patients with bilateral STN DBS placement and FOG at 130Hz even at usual medication "on" state.

You may not qualify if…

• Known history of recent aspiration pneumonia

Where it is running

• University of Chicago, Department of Neurology — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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