Assessment of the Tolerability of Dry Airflow in the Nasal Cavity During Sleep

Withdrawn before enrolling · Not applicable

Conditions studied: Healthy Adults

In brief

Preliminary data show that high flow nasal air has been shown to reduce promote heat exchange due to evaporation of nasal mucus by the air flow resulting in heat loss. It is unclear whether unidirectional nasal airflow is well tolerated in healthy individuals. The central hypothesis of this proposal is that dry high flow nasal air will be sufficiently tolerated in healthy adults.

Key facts

Study ID

NCT02547688

Run by

Johns Hopkins University

People needed

0

Starts

2015-01-01

Expected to finish

2018-01-01

Last updated by the study team

2017-08-08

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy men and women
• Able to consent
• Age ≥ 18
• BMI<30kg/m2

You may not qualify if…

• Previous diagnosis of obstructive sleep apnea or sleep disorder
• History of Constant Positive Airway Pressure treatment for Obstructive Sleep Apnea
• History of recurrent epistasis
• Pregnancy (self-report)
• Deviated nasal septum
• Unstable cardiovascular disease (decompensated Congestive Heart Failure, myocardial infarction or revascularization procedures, unstable arrhythmias)
• Uncontrolled hypertension with BP > 190/110
• Daytime hypoxemia with oxygen saturation<90% (measured at history and physical examination)
• Supplemental oxygen use
• Work in transportation industry as a driver or pilot.

Where it is running

• Johns Hopkins University — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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