Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer
Running, not enrolling · Phase 1
Conditions studied: Muscle Invasive Bladder Cancer
In brief
This is an open label, multi-drug, biomarker-directed, multi-centre, multi-arm, Phase 1b study in patients with muscle invasive bladder cancer (MIBC) (urothelial) who have progressed on prior treatment. This study is modular in design, allowing evaluation of the safety, tolerability, pharmacokinetics and anti-tumour activity of multiple agents as monotherapy and as combinations of different novel anti-cancer agents. The study will consist of a number of study modules (sub-studies), each evaluating the safety and tolerability of a specific agent or combination.
Key facts
- Study ID
- NCT02546661
- Run by
- AstraZeneca
- People needed
- 117
- Starts
- 2016-12-28
- Expected to finish
- 2026-01-30
- Last updated by the study team
- 2025-12-29
Who can join
Age: 18 and older, up to 130. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Research Site — Los Angeles, California, United States
- Research Site — New Haven, Connecticut, United States
- Research Site — Fort Myers, Florida, United States
- Research Site — New York, New York, United States
- Research Site — New York, New York, United States
- Research Site — New York, New York, United States
- Research Site — Cleveland, Ohio, United States
- Research Site — Nashville, Tennessee, United States
- Research Site — Edmonton, Alberta, Canada
- Research Site — Vancouver, British Columbia, Canada
- Research Site — Toronto, Ontario, Canada
- Research Site — Montreal, Quebec, Canada
- Research Site — Bordeaux, France
- Research Site — Caen, France
- Research Site — Lyon, France
- Research Site — Marseille, France
- Research Site — Saint-Herblain, France
- Research Site — Toulouse, France
- Research Site — Badalona, Spain
- Research Site — Barcelona, Spain
- Research Site — Barcelona, Spain
- Research Site — Madrid, Spain
- Research Site — Glasgow, United Kingdom
- Research Site — London, United Kingdom
- Research Site — London, United Kingdom
Full record on ClinicalTrials.gov
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