Comparability and Standardization of Controlled Allergen Challenge Facilities

Completed · Phase 4 · Has a placebo group

Conditions studied: Allergic Rhinitis

In brief

Allergen challenge facilities have been utilized for many years in clinical drug trials studying onset of action, proof of concept, duration of action, and efficacy. Each facility has somewhat different design characteristics and pollen dispersal technologies. Facilities are located in disparate geographic areas and have populations of participants who are sensitized to allergens unique to that area. Therefore, facilities have operated as single sites with little effort to evaluate facility comparability or to attempt standardization across facilities. The purpose of this study is to compare the two sites and assess whether the sites are able to achieve similar symptom scores.

Key facts

Study ID

NCT02543346

Run by

Queen's University

People needed

98

Starts

2015-10-01

Expected to finish

2016-05-01

Last updated by the study team

2019-04-09

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• history of rhinoconjunctivitis during ragweed season for a minimum of 2 years, including the previous 2 ragweed seasons.
• positive skin test to ragweed allergen.

You may not qualify if…

• participant is pregnant, lactating or actively trying to conceive.
• has a history of receiving immunotherapy containing short ragweed within the last 3 years.
• participant has current allergy symptoms.

Where it is running

• Biogenics Research Chamber — San Antonio, Texas, United States
• Kingston General Hospital — Kingston, Ontario, Canada

Full record on ClinicalTrials.gov

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