Fish Oil Brain Delivery Study

Completed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Brain Health

In brief

Docosahexaenoic acid (DHA) is an essential omega-3 fish oil. DHA is critical to the structure and function of brain cells. DHA fish oil has been shown to be beneficial in cognition in several animal studies; however, this effect in human studies is not clear. It is not known how much dietary fish oil can get into the human brain. Thus, exploring fish oil delivery in human brains is critical for designing appropriate interventions.

Key facts

Study ID

NCT02541929

Run by

University of Southern California

People needed

31

Starts

2016-06-30

Expected to finish

2019-09-30

Last updated by the study team

2020-03-31

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• ages 55 and above
• at risk of Alzheimer's disease such as family history of dementia
• women have to be postmenopausal

You may not qualify if…

• Current smokers (or a recent history of smoking within less than 5 years),
• Having a history of cardiovascular disease defined by a prior heart attack, coronary bypass or percutaneous luminal angioplasty, kidney failure or blindness.
• a diagnosis of cancer in the past 6 months, uncontrolled hyper- or hypothyroidism
• Taking anti-coagulants such as warfarin
• Anyone consuming n-3 PUFA capsules for the last 3 months.
• regular exercisers (>5 X30min of aerobic exercise per week),
• heavy drinkers (>30 units of alcohol per week). One unit of alcohol is about equal to: half a pint of ordinary strength beer, lager or cider (3-4% alcohol by volume); or. a small pub measure (25 ml) of spirits (40% alcohol by volume); or. a standard pub measure (50 ml) of fortified wine such as sherry or port (20% alcohol by volume)
• If participants have scores that lie 2 SD outside the means of the neuropsychiatry tests administered, they will have mild cognitive impairment. Participant's with mild cognitive impairment are excluded from this study.

Where it is running

• USC Keck School of Medicine — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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