Pilot Study Using Propranolol To Promote Prenylation Of Gtpase Rap1b In Hematopoietic Stem Cell Transplant Recipients
Completed
Conditions studied: Hematopoietic Stem Cell Transplantation
In brief
This is a an ancillary study designed to explore whether an additional cell signaling pathway (prenylation of Rap1) that was recently identified as being under beta-adrenergic control may be affected by beta-blocker use.
Key facts
- Study ID
- NCT02535182
- Run by
- Medical College of Wisconsin
- People needed
- 25
- Starts
- 2015-08-01
- Expected to finish
- 2020-02-01
- Last updated by the study team
- 2020-02-26
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with multiple myeloma receiving an autologous HCT are eligible when the following criteria are met:
- 18-75 years of age
- ≤ 1 year since initiation of systemic anti-myeloma therapy
- Patient is scheduled for autologous hematopoietic stem cell transplant as the upfront therapy for their multiple myeloma
- Karnofsky Performance Status of ≥90 %; patients eligible for HCT are eligible for the study
- All men and women must agree to practice effective contraception during the study period if not otherwise documented to be infertile.
You may not qualify if…
- Prior autologous HCT
- Non secretory multiple myeloma
- Concurrent beta-blocker therapy at or within 3 weeks of study entry.
- Previous intolerance to beta-blocker therapy
- Any medical contraindications to beta-blocker therapy including, but not limited to, symptomatic hypotension; drug hypersensitivity; sinus bradycardia, sick sinus syndrome, or 2nd or 3rd degree atrioventricular block without a pacemaker; uncompensated heart failure; or uncontrolled asthma
- Active, untreated depression screened for by the HCT physician (Patients who screen positive will be offered a referral to the MCW Psycho-Oncology program for further evaluation and treatment)
- Concurrent use of medications as specified in the protocol throughout the study or within one week of study entry.
- Pregnant or lactating women
Where it is running
- Froedtert Hospital and the Medical College of Wisconsin — Milwaukee, Wisconsin, United States
Full record on ClinicalTrials.gov
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