Outcome of Different Ablation Strategies In Persistent and Long-Standing Persistent Atrial Fibrillation

Completed · Phase 3

Conditions studied: Atrial Fibrillation

In brief

Specific Aim: This prospective randomized study aims to compare the impact of three different catheter ablation approaches on long-term procedure outcome in terms of arrhythmia recurrence in persistent (PeAF) and long-standing persistent atrial fibrillation (LSPAF) patients. The three strategies to be evaluated are 1) ablation at sources guided by FIRMap (using RhythmView™ Workstation from TOPERA), 2) ablation at sources guided by FIRMap + conventional pulmonary vein antrum isolation (PVAI) and 3) Extended PVAI plus ablation of non-PV triggers and complex fractionated atrial electrograms (CFAE).

Key facts

Study ID

NCT02533843

Run by

Texas Cardiac Arrhythmia Research Foundation

People needed

120

Starts

2014-04-01

Expected to finish

2017-07-01

Last updated by the study team

2018-04-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age: ≥ 18 years
• Patients presenting with persistent or long-standing persistent AF
• Undergoing first ablation procedure
• Ability to provide written informed consent

You may not qualify if…

• Reversible causes of atrial arrhythmia such as hyperthyroidism, pneumonia, pulmonary embolism, sarcoidosis and excessive alcohol consumption
• Prior ablation procedures
• Pregnancy

Where it is running

• Texas Cardiac Arrhythmia Institute, St. david's Medical Center — Austin, Texas, United States

Full record on ClinicalTrials.gov

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