Study of the Use of [18F]-DOPA in Hyperinsulinemic Hypoglycemia
NO_LONGER_AVAILABLE
Conditions studied: Hyperinsulinemic Hypoglycemia, Persistent, Congenital Hyperinsulinism, Persistent Hyperinsulinemic Hypoglycemia of Infancy (PHHI)
In brief
The primary objective of this study is to evaluate the utility of \[18F\]-DOPA PET to provide improved presurgical planning and distinguish between focal and diffuse forms of HI. The investigators will perform descriptive analysis, relying on visual analysis to diagnose and localize a focal lesion. Our findings will be compared to surgical histopathology to determine sensitivity and specificity or this technique. The investigators will also track patient surgical outcomes, specifically whether the patient is surgically "cured" or still requires medical management to control residual hypoglycemia.
Key facts
- Study ID
- NCT02533219
- Run by
- Baylor College of Medicine
- Last updated by the study team
- 2020-09-07
Who can join
Age: any, up to 64. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All Patients clinically diagnosed with Hyperinsulinemia of any age
- Patients in need of PET scan
- Patients that require sedation
- Patients that do not require sedation
You may not qualify if…
- Subjects presenting with any of the following will not be included in the study:
- Patients without Hyperinsulinemia
- Patients who are or may be pregnant
- Serious intercurrent medical illness other than hypoglycemia that precludes having the scan either because of patient instability or concerns about potential toxicity.
- Patient's requiring emergency surgical intervention that would be inappropriately delayed by [18F]-DOPA PET imaging.
Where it is running
- Texas Children's Hospital — Houston, Texas, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.