Third Party Viral Specific T-cells (VSTs)
Recruiting now · Phase 2
Conditions studied: Viral Infection, Viral Reactivation, Infection in an Immunocompromised Host
In brief
The purpose of this study is to demonstrate that viral specific T-cells (a type of white blood cell) can be generated from an unrelated donor and given safely to patients with viral infections.
Key facts
- Study ID
- NCT02532452
- Run by
- Children's Hospital Medical Center, Cincinnati
- People needed
- 750
- Starts
- 2015-09-02
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2025-12-16
Who can join
Age: 0 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Immunocompromised patient with evidence of viral infection or reactivation
- Age >1 day
- Recipients who have had a stem cell transplant must be at least 21 days after stem cell infusion
- Clinical status must allow tapering of steroids to < 0.5mg/kg prednisone or other steroid equivalent
- Must be able to receive CTL infusion in Cincinnati
- Informed consent obtained by PI or sub-investigator either in person or by phone
You may not qualify if…
- Active acute GVHD grades II-IV
- Uncontrolled bacterial or fungal infection
- Uncontrolled relapse of malignancy requiring treatment with chemotherapy
- Infusion of ATG or alemtuzumab within 2 weeks of VST infusion
- Biopsy confirmed acute rejection of solid organ transplant OR empiric treatment of suspected but not confirmed acute rejection of solid organ transplant within the last 30 days
Where it is running
- Akron Children's Hospital — Akron, Ohio, United States (enrolling)
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States (enrolling)
- The Ohio State University Wexner Medical Center - James Cancer Hospital — Columbus, Ohio, United States (enrolling)
- University of Cincinnati Medical Center — Cincinnati, Ohio, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.