Assessment of Optimal Egg Intake in a Healthy Population

Completed · Not applicable

Conditions studied: Cardiovascular Disease

In brief

Recently, the United States Department of Agriculture (USDA) has recommended removal of the 300mg/day limit on dietary cholesterol intake due to a lack of evidence supporting a connection between cholesterol intake and increased risk for cardiovascular disease (CVD). Previous work has shown that daily intake of eggs actually favorably alters many parameters associated with CVD risk. Conversely, emerging research suggests that choline, a nutrient in eggs, may be converted into trimethylamine oxide (TMAO) by the intestinal microbiota. TMAO is thought to increase the risk for CVD. Therefore, the purpose of this study is to determine a threshold of daily egg intake at which the risk for CVD is not negatively impacted in a young, healthy population.

Key facts

Study ID

NCT02531958

Run by

University of Connecticut

People needed

38

Starts

2015-08-14

Expected to finish

2017-05-31

Last updated by the study team

2017-06-27

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• BMI 18.5-29.9 kg/m2
• Proficient in English
• Cholesterol ≤ 240 mg/dL
• Willing to consume 1, 2, and 3 eggs per day for 4 weeks each

You may not qualify if…

• Diabetes mellitus, cardiovascular disease, history of stroke, renal disease, liver disease, cancer, or eating disorder
• Taking glucose-lowering supplements or medications
• Taking triglyceride-lowering medications, bile acid sequestrants, or high-dose chromium or cinnamon supplements
• Plasma glucose < 126 mg/dL, triglycerides > 500 mg/dL, or blood pressure > 140/90 mmHg (average of 3 readings)
• Allergy to eggs

Where it is running

• University of Connecticut — Storrs, Connecticut, United States

Full record on ClinicalTrials.gov

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