Methoxsalen and Extracorporeal Photopheresis (ECP) for the Treatment of Pediatric Participants With Steroid Refractory Acute Graft Versus Host Disease
Stopped early · Phase 3
Conditions studied: Steroid Refractory Acute Graft Versus Host Disease
In brief
This is a single-arm, open-label, multicenter study of the efficacy of UVADEX® (methoxsalen) Sterile Solution in conjunction with THERAKOS® CELLEX® Photopheresis Systems (ECP) in pediatric participants with steroid-refractory aGvHD. The study is composed of Screening, Treatment, and Follow-up Periods.
Key facts
- Study ID
- NCT02524847
- Run by
- Therakos, Inc., a Mallinckrodt Company
- People needed
- 29
- Starts
- 2016-01-20
- Expected to finish
- 2019-07-16
- Last updated by the study team
- 2020-09-11
Who can join
Age: 1 and older, up to 21. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Phoenix Children's Hospital — Phoenix, Arizona, United States
- Children's Hospital of Los Angeles — Los Angeles, California, United States
- Yale University — New Haven, Connecticut, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- Children's Healthcare of Atlanta, Emory - Children's Center — Atlanta, Georgia, United States
- Lurie Children's Hospital — Chicago, Illinois, United States
- Boston Children's Hospital — Boston, Massachusetts, United States
- St. Louis Children's Hospital — St Louis, Missouri, United States
- Hackensack University Medical Center — Hackensack, New Jersey, United States
- University Hospitals Rainbow Babies & Children's — Cleveland, Ohio, United States
- Cleveland Clinic Children's — Cleveland, Ohio, United States
- Oregon Health and Science University — Portland, Oregon, United States
- Vanderbilt University Medical Center - Ingram Cancer Institute — Nashville, Tennessee, United States
- MD Anderson Cancer Care Center — Houston, Texas, United States
- University of Utah — Salt Lake City, Utah, United States
- Fred Hutchinson Cancer Research Center — Seattle, Washington, United States
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States
- St Anna Kinderspital — Vienna, Austria
- Hopital Necker Enfants Malades — Paris, France
- Hôpital universitaire Robert Debré — Paris, France
- Universitätsklinikum Leipzig, Klinik und Poliklinik für Kinder- und Jugendmedizin, Abteilung für Hämatologie und Internistische Onkologie — Leipzig, Germany
- Klinikum rechts der Isar, TU München, Klinik- und Poliklinik für Kinder- und Jugendmedizin, Kinderklinik München Schwabing — München, Germany
- University Hospital Tuebingen — Tübingen, Germany
- Universitaetsklinikum Ulm, Kinder- und Jugendmedizin — Ulm, Germany
- United St Istvan and St Laszlo Hospital — Budapest, Hungary
Full record on ClinicalTrials.gov
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