Description of Fluid Balance in Patients With Acute Respiratory Failure

Status unconfirmed

Conditions studied: Respiratory Insufficiency

In brief

The specific aim of this study is to gather data on fluid balance, intravenous medication administration, electrolyte balance, and diuretic and dialysis use in patients with acute respiratory failure who might benefit from a strategy designed to limit fluid administration.

Key facts

Study ID

NCT02523872

Run by

Smiths Medical, ASD, Inc.

People needed

50

Starts

2015-08-01

Expected to finish

2015-12-01

Last updated by the study team

2015-08-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Intubation and mechanical ventilation for ≤ 7 days
• An underlying condition associated with acute respiratory failure (e.g. pneumonia, ARDS, sepsis, asthma, COPD exacerbation)
• If in shock (MAP < 60, fluid bolus ≥30 ml/Kg or 4 L crystalloid or equivalent, vasopressors except for dopamine ≤ 5 mcg/kg/min or low-dose (≤ 0.04 IU/min) vasopressin) there should be no fluid bolus (1000 mL crystalloid or equivalent) for at least 12 hours

You may not qualify if…

• Intubation or mechanical ventilation for > 7 days
• Respiratory failure (requirement for positive pressure ventilation) in past 30 days
• Shock (MAP < 60, fluid bolus ≥30 ml/Kg or 4 L crystalloid or equivalent, vasopressors except for dopamine ≤ 5 mcg/kg/min or low-dose vasopressin) requiring fluid bolus (1000 mL crystalloid or equivalent) within past 12 hours
• Presence of a condition making it unlikely that the patient will be liberated from mechanical ventilation within the next 28 days (e.g. quadriplegia, end-stage lung disease, massive stroke, etc.)
• Prognosis from underlying condition ≤ 28 days (estimated 28 day mortality from underlying condition >50%)
• Likely intention (>50% probability) to withhold or withdraw life-supportive care within next 28 days

Where it is running

• University of Maryland Medical Center — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.