Effects of PEEP on Heart and Lungs in Obese Subjects

Status unconfirmed · Not applicable

Conditions studied: Obesity, Pulmonary Atelectasis, Obesity Hypoventilation Syndrome, Magnetic Resonance Imaging, Respiratory Mechanics, Electrical Impedance Tomography, Trans-Thoracic Echocardiography

In brief

Aim of this study is to better understand pathophysiology of the alteration of respiratory mechanics and cardiovascular function in obese volunteer subjects. The investigators plan to test this hypothesis with a physiological, interventional study conducted on volunteers by using Electrical Impedance Tomography in a group of patients and magnetic resonance imaging (MRI) in another group.

Key facts

Study ID

NCT02523352

Run by

Massachusetts General Hospital

People needed

35

Starts

2018-04-05

Expected to finish

2022-12-31

Last updated by the study team

2020-11-17

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Have a photo identification document
• BMI ≥ 35 kg/m2
• Waist circumference > 88 cm (for women)
• Waist circumference > 102 cm (for men)

You may not qualify if…

• Psychiatric disturbances such as anxiety, depression, schizophrenia requiring pharmacological treatment or hospitalization in the last year
• Subjects with any known condition, including claustrophobia or pain, which limits their ability to lie in the MR scanner for the duration of the research study
• Known presence of esophageal varices
• Recent esophageal trauma or surgery
• Known Coagulopathy
• History of pneumothorax
• Pregnancy
• Diabetes
• Presence of prosthesis incompatible with MR
• Thoracic diameter grater than 70 cm
• Resting heart rate (HR) < 50 or > 120 bpm and/or systolic blood pressure < 90 or > 160 mmHg and/or peripheral oxygen saturation (SpO2) < 88%
• Currently enrolled in another research study

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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