Dietary Treatments for Cognitive Impairment in Older Adults

Completed · Not applicable

Conditions studied: Mild Cognitive Impairment, Probable Alzheimer's Disease

In brief

This trial seeks to establish the feasibility of implementing a ketogenic, modified Atkins diet (MAD) to older adults with mild cognitive impairment (MCI) or early Alzheimer's disease (AD) living in the community. A secondary aim is to determine whether adherence to the MAD results in better cognitive test scores than adherence to a non-ketogenic control diet. A final aim is to determine the role of apolipoprotein E (ApoE) genotype in participants' response to the MAD. Participants will be randomly assigned to a 12-week trial of either the MAD or a placebo diet based on the National Institute on Aging's recommendations for senior nutrition.

Key facts

Study ID

NCT02521818

Run by

Johns Hopkins University

People needed

38

Starts

2015-08-01

Expected to finish

2019-07-01

Last updated by the study team

2019-09-06

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• diagnosis of mild cognitive impairment or Alzheimer's disease
• availability of cohabitating study partner without cognitive impairment
• consent of primary care physician

You may not qualify if…

• history of stroke
• history of coronary artery disease
• history of pancreatitis
• untreated hypothyroidism or B12 deficiency
• history of renal disease or recurrent kidney stones
• history of liver disease
• insulin-dependent diabetes
• body mass index <18.5
• multiple food allergies
• follow strict diet (e.g., vegetarian, gluten-free)

Where it is running

• Johns Hopkins Hospital — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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