The Effects of Probiotic Supplementation on Markers of Muscle Damage and Performance Following Exercise Induced Muscle Damage

Completed · Phase 2 · Has a placebo group

Conditions studied: Probiotics

In brief

To determine the effect of probiotic supplementation on the inflammatory response and subsequent performance following a muscle damaging exercise bout, a double-blind, randomized placebo controlled two-factor repeated measures design will be employed. The dependent variables for this study will include measures of performance as well as markers of inflammation in a single limb model. Participants who qualify for study participation will have their height, weight, and body composition assessed (skin fold) followed by baseline measurements for determination of isometric and dynamic strength. Initial limb will be determined randomly. Following baseline testing, participants will randomly be assigned to ingest either a probiotic or placebo. Supplementation will begin at least 24 hours post baseline testing. Twenty-one days after initiating supplementation, participants will again complete performance testing followed by an exercise bout known to elicit muscle damage and produce an inflammatory response. Participants will then repeat performance testing 24, 48, and 72 hours post muscle damaging bout. Blood samples for determination of markers of inflammation will be taken throughout study duration. Following a 3-week wash-out period (21 days), participants will repeat the experiment following the alternate supplement regimen with the contralateral limb.

Key facts

Study ID

NCT02520583

Run by

Texas Christian University

People needed

15

Starts

2015-02-01

Expected to finish

2015-08-01

Last updated by the study team

2016-10-19

Who can join

Age: 18 and older, up to 35. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Participants must currently be participating in structured resistance training and must have been doing so for the previous 1 year period.

You may not qualify if…

• Having consumed any nutritional supplements and/or ergogenic aids for the preceding 6 week period.
• Having not taken any anti-inflammatory medications for the previous month.

Where it is running

• Texas Christian Universti — Fort Worth, Texas, United States

Full record on ClinicalTrials.gov

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