BI 894999 First in Human Dose Finding Study in Advanced Malignancies

Completed · Phase 1

Conditions studied: Neoplasms, NUT Carcinoma

In brief

This study is open to adults with different types of advanced cancer (solid tumours). The study is also open to patients with diffuse large B-cell lymphoma in whom previous treatment was not successful. In some countries, adolescents who are at least 15 years old and who are diagnosed with NUT carcinoma can also participate. No standard treatment exists for this rare and aggressive form of cancer. The purpose of this study is to find out the highest dose of BI 894999 that people can tolerate. BI 894999 is tested for the first time in humans. Participants take tablets once daily. The study also tests whether participants can tolerate BI 894999 better when taken continuously or with breaks in between. Participants can stay in the study as long as they benefit from the treatment and can tolerate it. The doctors also regularly check the general health of the participants.

Key facts

Study ID: NCT02516553
Run by: Boehringer Ingelheim
People needed: 174
Starts: 2015-07-08
Expected to finish: 2021-11-23
Last updated by the study team: 2024-04-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

For all patients
Age 18 years or older at the time of signature of the informed consent.
Life expectancy of at least 12 weeks after the start of the treatment according to the investigator's judgement
Male or female patients. Women of childbearing potential* must be ready and able to use highly effective methods of birth control per ICH M3(R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria is provided in the patient information. For women of childbearing potential using a contraceptive pill, an additional barrier method is necessary due to the potential CYP3A4 inducing effect of BI894999. Male patients having a partner of childbearing potential must use condoms and ensure their partner is using a highly effective method of birth control as described above, during the trial and for at least three months after the end of the trial * Any female who has experienced menarche and does not meet the criteria for "women not of childbearing potential" as described below.
Women not of childbearing potential are defined as: women who are postmenopausal (12 months with no menses without an alternative medical cause) or who are permanently sterilized (e.g., tubal occlusion, hysterectomy, bilateral oophorectomy or bilateral salpingectomy).
Written informed consent consistent with ICH-GCP and local legislation
For patients with solid tumours
Patients with a histologically or cytologically confirmed diagnosis of an advanced unresectable and/or metastatic, malignant solid tumour, who have failed conventional treatment or for whom no therapy of proven efficacy exists, or who are not amenable to standard therapies
Age ≥ legal age to be adult for the given country at the time of signature of the informed consent. For NC patients, age 15 years or older at the time of signature of the informed consent ( in Germany and South Korea, only legally adult patients may be included
Eastern Cooperative Oncology Group (ECOG, R01-0787) performance score 0 or 1 at the time of screening. A score of 2 is allowed for NUT carcinoma patients
Recovery of therapy-related toxicities from previous chemotherapy, tyrosine kinase inhibitors, hormone therapy, immunotherapy, antibodies, vaccine therapy, or radiotherapy to CTCAE ≤ grade 1 (with the exception of alopecia, peripheral sensory neuropathy grade 2)
Life expectancy of at least 12 weeks after the start of the treatment according to the investigator's judgement
Male or female patients. Women of childbearing potential* must be ready and able to use highly effective methods of birth control per ICH M3(R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria is provided in the patient information. For women of childbearing potential using a contraceptive pill, an additional barrier method is necessary due to the potential CYP3A4 inducing effect of BI894999. Male patients having a partner of childbearing potential must use condoms and ensure their partner is using a highly effective method of birth control as described above, during the trial and for at least three months after the end of the trial treatment
Written informed consent consistent with ICH-GCP and local legislation. For adolescent NC patients aged 15 years to < legal adult age, written assent of the patient and written informed consent of the parents (both or one according to national regulation) or legal guardian of the adolescent
Written informed consent for tumour biopsies in the escalation phase Ia
Optional for those patients until extension of the MTD cohort,
Optional for the patients in the extension of MTD cohort at the same time points as described below for the expansion phase. For these patients in the extension of the MTD cohort, if they have an accessible lesion for biopsy, they will be offered optional consent for tumour biopsies
In addition, all patients included in the expansion Phase Ib must:
Have been diagnosed with one of the four types of tumours selected:
small cell lung cancer (SCLC)
metastatic castrate resistant prostate cancer (mCRPC)
colorectal cancer (CRC)
NUT carcinoma (NC) (for which the "midline" origin is not a prerequisite)
Have failed conventional treatments or who are not amenable to standard therapies (per criterion 1) that specifically include for:
SCLC: a platinum-based therapy (previous treatment with topotecan is not mandatory)

You may not qualify if…

For all patients:
Inability to swallow tablets
Additional other serious illness, concomitant non-oncological disease (e.g. active infectious disease including an active infection with SARS-CoV-2 confirmed by a PCR test or had one in the prior 6 weeks or active hepatitis (Hep) B infection as defined by positive Hep B DNA test, active Hep C infection as defined by positive Hep C RNA test and human immunodeficiency virus (HIV) infection (positive result in established HIV diagnostic assay), or ongoing toxicity from prior therapies considered by the investigator to potentially compromise patient's safety in this trial
Serum creatinine greater than 1.5 mg/dL (>132 µmol/L, SI unit equivalent)
Women who are pregnant, nursing, or who plan to become pregnant while in the trial
Treatment with other investigational drugs or participation in another clinical interventional trial within the past four weeks or within five times the half-life of the previous investigational drug, whichever is shorter, before start of therapy or concomitant with this trial
Patients unable to comply with the protocol
Patients who are actively abusing alcohol or drugs. Since no alcohol or drug testing is required per protocol, it is at the investigator's discretion to determine abuse.
For patients with solid tumours:
Additional other serious illness , concomitant non-oncological disease (e.g. active infectious disease or known chronic Hepatitis B/Hepatitis C infection and HIV), or ongoing toxicity from prior therapies considered by the investigator to potentially compromise patient's safety in this trial
History or presence of cardiovascular abnormalities deemed clinically relevant by the investigator such as uncontrolled hypertension, congestive heart failure NYHA classification of 3, unstable angina or poorly controlled arrhythmia. Myocardial infarction within 6 months prior to study entry.Left Ventricular Ejection Fraction (LVEF) less than 50% at baseline
Clinical evidence of symptomatic progressive brain or leptomeningeal disease during the last 28 days before the start of treatment with BI 894999
Absolute neutrophil count less than 1500/mm\^3
Platelet count less than 100 000/mm\^3
Bilirubin greater than 1.5 mg/dL (>26 µmol/L, SI unit equivalent) (except known Gilbert's syndrome, accepted up to 2 mg/dL or up to 34.2 µmol/L in this case)
Aspartate amino transferase (AST) and/or alanine amino transferase (ALT) greater than 2.5 times the upper limit of normal (if related to liver metastases, greater than five times the upper limit of normal)
Treatment with other investigational drugs or participation in another clinical interventional trial within the past four weeks (past two weeks for NC patients) or within five times the half-life of the previous investigational drug, whichever is the shorter, before start of therapy or concomitant with this trial
Systemic anti-cancer therapy within four weeks (past two weeks for NC patients) or five times the half-life of the drug, whichever is shorter. Radiotherapy given for curative intent or other than palliative radiotherapy within the past four weeks before start of therapy or concomitantly with this trial. This These restrictions does not apply to LHRH agonists or antagonists, steroids (given at a stable dose in the last four weeks) used for palliative intent, bisphosphonates, and denosumab and to palliative radiotherapy (no wash out required)
For patients with DLBCL:
Patient is eligible for curative salvage high dose therapy followed by stem cell transplant.
Primary central nervous system (CNS) lymphoma or known CNS involvement
Prior allogeneic bone marrow or stem cell transplant
High-dose therapy with stem cell support <3 months prior to visit 1
AST or ALT >2.5 x upper limit of normal (CTCAE grade 2 or higher)
Total bilirubin >1.5 x upper limit of normal (CTCAE grade 2 or higher)

Where it is running

Dana-Farber Cancer Institute — Boston, Massachusetts, United States
Memorial Sloan-Kettering Cancer Center — New York, New York, United States
Cleveland Clinic — Cleveland, Ohio, United States
The University of Texas MD Anderson Cancer Center — Houston, Texas, United States
Brussels - HOSP Jules Bordet — Anderlecht, Belgium
Brussels - UNIV Saint-Luc — Brussels, Belgium
UNIV UZ Gent — Ghent, Belgium
UZ Leuven — Leuven, Belgium
HOP Timone — Marseille, France
HOP Hôtel-Dieu — Nantes, France
HOP Saint-Louis — Paris, France
INS Gustave Roussy — Villejuif, France
Universitätsklinikum Tübingen — Tübingen, Germany
Samsung Medical Center — Seoul, South Korea
Hospital Vall d'Hebron — Barcelona, Spain
Hospital Universitario 12 de Octubre — Madrid, Spain

Full record on ClinicalTrials.gov

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