Ixazomib Citrate, Lenalidomide, Dexamethasone, and Zoledronic Acid or Zoledronic Acid Alone After Radiation Therapy in Treating Patients With Solitary Plasmacytoma of Bone
Stopped early · Phase 3
Conditions studied: Solitary Osseous Plasmacytoma
In brief
This randomized phase III trial compares ixazomib citrate, lenalidomide, dexamethasone and zoledronic acid with zoledronic acid alone to see how well they work when given after radiation therapy in treating patients with solitary plasmacytoma of bone. Ixazomib citrate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Lenalidomide may help the immune system kill abnormal blood cells or cancer cells. Dexamethasone is a drug used in chemotherapy that may cause tumor cells to die. Zoledronic acid may prevent bone fractures and reduce bone pain, and may also improve survival. Standard treatment for this cancer is radiation therapy alone. It is not yet known whether ixazomib citrate, lenalidomide, dexamethasone and zoledronic acid or zoledronic acid alone is more effective, and whether adding these treatments after radiation therapy is more effective than radiation therapy alone in treating patients with solitary plasmacytoma of bone.
Key facts
- Study ID
- NCT02516423
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 11
- Starts
- 2016-11-29
- Expected to finish
- 2025-09-30
- Last updated by the study team
- 2026-06-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Anchorage Radiation Therapy Center — Anchorage, Alaska, United States
- Alaska Breast Care and Surgery LLC — Anchorage, Alaska, United States
- Alaska Oncology and Hematology LLC — Anchorage, Alaska, United States
- Alaska Women's Cancer Care — Anchorage, Alaska, United States
- Anchorage Oncology Centre — Anchorage, Alaska, United States
- Katmai Oncology Group — Anchorage, Alaska, United States
- Providence Alaska Medical Center — Anchorage, Alaska, United States
- Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank, California, United States
- University Oncology Associates — Clovis, California, United States
- Epic Care-Dublin — Dublin, California, United States
- Bay Area Breast Surgeons Inc — Emeryville, California, United States
- Epic Care Partners in Cancer Care — Emeryville, California, United States
- California Cancer Center - Fresno — Fresno, California, United States
- Scripps Cancer Center — La Jolla, California, United States
- Contra Costa Regional Medical Center — Martinez, California, United States
- Alta Bates Summit Medical Center - Summit Campus — Oakland, California, United States
- Bay Area Tumor Institute — Oakland, California, United States
- Epic Care Cyberknife Center — Walnut Creek, California, United States
- Grand Valley Oncology — Grand Junction, Colorado, United States
- Saint Alphonsus Cancer Care Center-Boise — Boise, Idaho, United States
- Saint Luke's Mountain States Tumor Institute — Boise, Idaho, United States
- Saint Alphonsus Cancer Care Center-Caldwell — Caldwell, Idaho, United States
- Kootenai Medical Center — Coeur d'Alene, Idaho, United States
- Walter Knox Memorial Hospital — Emmett, Idaho, United States
- Anchorage Associates in Radiation Medicine — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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