18F-AV-1451 Autopsy Study

Completed · Phase 3

Conditions studied: Alzheimer's Disease

In brief

This study is designed to test the relationship between ante-mortem flortaucipir Positron Emission Tomography (PET) imaging and tau neurofibrillary pathology associated with Alzheimer's disease (AD), as measured at autopsy.

Key facts

Study ID

NCT02516046

Run by

Avid Radiopharmaceuticals

People needed

156

Starts

2015-09-01

Expected to finish

2018-07-15

Last updated by the study team

2020-09-07

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a projected life expectancy of ≤ 6 months
• Can tolerate a 20 minute PET scan
• Give informed consent or have a legally authorized representative to consent for study procedures and brain donation consistent with the legal requirements of the State in which they die

You may not qualify if…

• Aggressively being treated with life sustaining measures
• Known to have a structural brain lesion that would interfere either with PET imaging or pathological assessment
• Clinically significant infectious disease
• Currently receiving any investigational medications except with permission from the study sponsor
• Participated in an experimental study with an amyloid or tau targeting agent
• Suspected encephalopathy due to alcoholism or end-stage liver disease
• Females of childbearing potential
• History of risk factors for Torsades de Pointes or are currently taking medication known to cause QT prolongation

Where it is running

• Banner Alzheimer's Institute — Phoenix, Arizona, United States
• St. Joseph's Hospital and Medical Center — Phoenix, Arizona, United States
• Cherlin Research — Los Gatos, California, United States
• Hoag Memorial Hospital Presbyterian — Newport Beach, California, United States
• California Research Foundation — San Diego, California, United States
• Pacific Research Network — San Diego, California, United States
• Ray Dolby Brain Health Center — San Francisco, California, United States
• Syrentis Clinical Research — Santa Ana, California, United States
• Neuropsychiatric Research Center of Southwest Florida — Fort Myers, Florida, United States
• Galiz Research — Hialeah, Florida, United States
• Merritt Island Medical Research — Merritt Island, Florida, United States
• Miami Jewish Health Systems — Miami, Florida, United States
• D de la Vega MD Research Group — Miami, Florida, United States
• Bioclinica — Orlando, Florida, United States
• Emory University Brain Health Center — Atlanta, Georgia, United States
• Alzheimer's Disease Center — Quincy, Massachusetts, United States
• Steinberg Diagnostics — Henderson, Nevada, United States
• Adirondack Medical Research Center — Glens Falls, New York, United States
• Clarity Clinical Research, LLC — Syracuse, New York, United States
• Duke University Medical Center — Durham, North Carolina, United States
• Wake Forest School of Medicine — Winston-Salem, North Carolina, United States
• Valley Medical Primary Care — Centerville, Ohio, United States
• Hospice of the Western Reserve — Cleveland, Ohio, United States
• American Clinical Trials, LLC (Site 1216) — Oklahoma City, Oklahoma, United States
• Oklahoma Behavioral Health — Oklahoma City, Oklahoma, United States

Full record on ClinicalTrials.gov

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