Memory Modulation by Pain During Anesthesia

Completed · Phase 1

Conditions studied: Amnesia, Pain, Anesthesia

In brief

The purpose of this study is to determine the effects of pain on facilitating long-term auditory memory in the presence and absence of distinct intravenous anesthetics. The ability to identify previously presented words from a list assessed the degree of memory formation. In a subset of subjects, functional magnetic resonance imaging was used to identify the neural correlates of memory inhibition or facilitation by the combination of pain and anesthetic used.

Key facts

Study ID

NCT02515890

Run by

University of Pittsburgh

People needed

32

Starts

2015-11-19

Expected to finish

2018-12-12

Last updated by the study team

2020-07-01

Who can join

Age: 18 and older, up to 39. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy adult volunteers, with normal memory and hearing, whose native language is English

You may not qualify if…

• pregnancy
• significant memory or hearing loss
• sleep apnea
• chronic pain
• metal or electronic implants
• claustrophobia
• Currently taking: antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, sleep-aids, or pain medication

Where it is running

• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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