A Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of Isatuximab in Patients With Multiple Myeloma

Completed · Phase 1

Conditions studied: Plasma Cell Myeloma

In brief

Primary Objective: * Part A: To evaluate the safety of SAR650984 (isatuximab) in patients with relapsed/refractory multiple myeloma (RRMM). * Part B: To evaluate the activity of SAR650984 (isatuximab) as assessed by overall response rate (ORR) in RRMM patients previously treated with daratumumab. Secondary Objectives: * Part A: * To determine the pharmacokinetics (PK) of SAR650984 (isatuximab) in patients with RRMM. * Part B: * To evaluate the safety of SAR650984 (isatuximab). * To evaluate the efficacy of SAR650984 (isatuximab) as assessed by duration of response (DOR), clinical benefit rate (CBR) and progression free survival (PFS). * To assess the pharmacokinetics (PK) of SAR650984 (isatuximab) and daratumumab at baseline. * To evaluate the immunogenicity of SAR650984 (isatuximab).

Key facts

Study ID

NCT02514668

Run by

Sanofi

People needed

55

Starts

2015-09-01

Expected to finish

2021-12-02

Last updated by the study team

2022-04-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Part A
• Patients must have a known diagnosis of multiple myeloma (MM) with evidence of measurable disease, as defined below, and have evidence of disease progression based on International Myeloma Working Group (IMWG) criteria:
• Serum M-protein ≥1g/dL, or urine M-protein ≥200 mg/24 hours, OR
• In the absence of measurable M-protein, serum immunoglobulin free light chain ≥10 mg/dL, and abnormal serum immunoglobulin kappa lambda free light chain ratio.
• Patients must have received at least 3 prior lines of therapy for MM and must include treatment with an immunomodulatory drug (IMiD) (for ≥2 cycles or ≥2 months of treatment) and a proteasome inhibitor (for ≥2 cycles or ≥2 months of treatment). Induction therapy and stem cell transplant (± maintenance) will be considered as one regimen within a line, OR
• Patients whose disease is double refractory to an IMiD and a proteasome inhibitor. For patients who have received more than one type of IMiD and proteasome inhibitor, their disease must be refractory to the most recent one.
• Patients must have achieved a minimal response (MR) or better to at least one prior line of therapy.
• Patients must have received an alkylating agent (for ≥2 cycles or ≥2 months of treatment) either alone or in combination with other MM treatments (history of stem cell transplant is acceptable). Treatment with high-dose Melphalan for stem cell transplantation meets this requirement.
• Signed written informed consent and be willing and able to complete all study-related procedures.
• Part B
• Patients must have a known diagnosis of multiple myeloma (MM) with evidence of measurable disease, as defined below, and have evidence of disease progression based on International Myeloma Working Group (IMWG) criteria:
• Serum M-protein ≥1g/dL, or urine M-protein ≥200 mg/24 hours, OR
• In the absence of measurable M-protein, serum immunoglobulin free light chain ≥10 mg/dL, and abnormal serum immunoglobulin kappa lambda free light chain ratio.
• Patients must have received at least 3 cycles of daratumumab treatment with at least 6 weeks from the last treatment with daratumumab to the first study treatment OR at least 2 cycles of daratumumab treatment in case another therapy is given between daratumumab and isatuximab with at least 12 weeks from the last treatment with daratumumab to the first study treatment.
• Patients must have achieved MR or better to at least 1 prior line of therapy.
• Signed written informed consent and be willing and able to complete all study-related procedures.

You may not qualify if…

• Patients <18 years old.
• Eastern Cooperative Oncology Group (ECOG) performance status >2.
• Poor bone marrow reserve.
• Poor organ function.
• Known intolerance/hypersensitivity to IMiDs, dexamethasone, boron or mannitol, sucrose, histidine, or polysorbate 80.
• Any serious active disease (including clinically significant infection that is chronic, recurrent, or active) or comorbid condition, which, in the opinion of the Investigator, could interfere with the safety, the compliance with the study, or with the interpretation of the results.
• Any severe underlying medical conditions including presence of laboratory abnormalities, which could impair the ability to participate in the study or the interpretation of its results.
• The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Where it is running

• Investigational Site Number 840003 — Scottsdale, Arizona, United States
• Investigational Site Number 840004 — San Francisco, California, United States
• Investigational Site Number 840011 — Detroit, Michigan, United States
• Investigational Site Number 840015 — St Louis, Missouri, United States
• Investigational Site Number 840005 — Hackensack, New Jersey, United States
• Investigational Site Number 840010 — Durham, North Carolina, United States
• Investigational Site Number 840013 — Canton, Ohio, United States
• Investigational Site Number 840001 — Nashville, Tennessee, United States
• Investigational Site Number 840002 — Salt Lake City, Utah, United States
• Investigational Site Number 840006 — Milwaukee, Wisconsin, United States
• Investigational Site Number 203002 — Brno, Czechia
• Investigational Site Number 203001 — Prague, Czechia
• Investigational Site Number 250008 — Créteil, France
• Investigational Site Number 250005 — Montpellier, France
• Investigational Site Number 250002 — Nantes, France
• Investigational Site Number 250004 — Pessac, France
• Investigational Site Number 250001 — Poitiers, France
• Investigational Site Number 250006 — Vandœuvre-lès-Nancy, France

Full record on ClinicalTrials.gov

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